Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis.
نویسندگان
چکیده
JC virus (JCV) DNA was detected in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy (PML) but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. This suggests that inflammatory processes in the brain do not necessarily reactivate JCV, which further supports the proposal that the presence of JCV DNA in the CSF is diagnostic for PML.
منابع مشابه
Detection of Herpes Simplex Virus Infection in Cerebrospinal Fluid
ABSTRACT Background and Objective: Herpes simplex encephalitis is a life-threatening consequence of the central nervous system (CNS) infection with Herpes simplex virus (HSV). Although it is a rare disease, mortality rates reach 70% in the absence of therapy and only a minority of individuals can return to normal function. The aim of this study was to d...
متن کاملInfrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy
Conflicting prevalence of newly identified KI (KIPyV), WU (WUPyV) and Merkel Cell Carcinoma (MCPyV) polyomaviruses have been reported in progressive multifocal leukoencephalopathy (PML) patient samples, ranging from 0 to 14.3%. We analyzed the prevalence of these polyomaviruses in cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMC), and bone marrow samples from PML patients, im...
متن کاملDetection of WU polyomavirus in cerebrospinal fluid specimen from a patient with AIDS and suspected progressive multifocal leukoencephalopathy.
To the Editor—We read with interest the article recently published in the Journal of Infectious Diseases by Sharp et al. [1], who investigated whether the newly discovered KI, WU, and Merkel cell poly-omaviruses could persist and reactivate in immunodeficient patients. To this aim, the authors screened for the presence of ge-nomic sequences of KI, WU, and Merkel cell polyomaviruses, in addition...
متن کاملDetection of human herpesviruses in the cerebrospinal fluid from patients diagnosed with or suspected of having progressive multifocal leukoencephalopathy
BACKGROUND Progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients. While JCV DNA is detected in the cerebrospinal fluid (CSF) from a certain proportion of patients suspected of having PML, JCV-negative patients may also develop brain lesions due to other infectious agents. This study assessed the prev...
متن کاملProgressive multifocal leukoencephalopathy, a possible complication in a patient with bladder cancer
Received: October 02, 2015; Accepted: October 20, 2015; Published: October 23, 2015 Abbreviations: PML: Progressive Multifocal Leukoencephalopathy; JCV: John Cunningham Virus; AIDS: Acquired Immune Deficiency Syndrome; CSF: Cerebrospinal Fluid; HIV: Human Immuno deficiency Virus; HSV: Herpes Simplex Virus; VZV: Varicella Zoster Virus; CMV: Cytomegalovirus; ADC: Apparent Diffusion Coefficient; S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of clinical microbiology
دوره 36 4 شماره
صفحات -
تاریخ انتشار 1998